This article explores the need for an integrated approach that includes private pharmacies to meet the growing demand for HIV and AIDS prevention, care, and treatment services in South Africa. The state of the epidemic is presented as are policy recommendations for an integrated approach. Five themes are discussed: public-private partnerships, HIV/AIDS resource centers in pharmacies, antiretroviral therapy, task shifting and task sharing, and interprofessional obstacles. The article concludes by providing policy recommendations for further research to facilitate partnerships and encourage greater research in this field. It also highlights the need for patient-centered partnerships and incentives for task sharing.